منابع مشابه
Combined abnormalities of semilunar valves: quadricuspid pulmonary and bicuspid aortic valves.
A42-year-old man was referred to our hospital for evaluation of systolic and diastolic murmurs at the left sternal border. Transthoracic 2D echocardiography revealed a quadricuspid pulmonary valve (Figure 1A) and a bicuspid aortic valve (Figure 1B). Transvalvular flow velocities at the pulmonary and aortic valves were 1.8 m/s and 1.7 m/s, respectively, suggesting mild pulmonary stenosis. Additi...
متن کاملReview article: Tissue engineering of semilunar heart valves: current status and future developments.
Heart valve replacement represents the most common surgical therapy for end-stage valvular heart diseases. One major drawback that all heart valve replacements have in common is the lack of growth, repair, and remodeling capability once implanted into the body. The emerging field of tissue engineering is focusing on the in-vitro generation of functional, living semilunar heart valve replacement...
متن کاملAccumulation of oxidized LDL in human semilunar valves correlates with coronary atherosclerosis.
OBJECTIVE Recent data indicate that oxidized low-density lipoprotein (ox-LDL) has several proatherogenic effects, e.g. induction of macrophage chemoattractants, adhesion molecules, cytokines, type-1 plasminogen activator inhibitor and platelet-derived growth factor A-chain by smooth muscle cells. Therefore, ox-LDL has been utilized as a marker of oxidative modification of proteins in atheroscle...
متن کاملEndothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract
BACKGROUND Congenital heart disease is the most common type of birth defect, affecting ≈2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bicuspid aortic valve, which has an estimated prevalence of 1% in the population. We previously reported that mutations in NOTCH1 were a cause of bicuspid ao...
متن کاملCardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves.
Congenital anomalies of the aortic valve are common and are associated with progressive valvular insufficiency and/or stenosis. In addition, aneurysm, coarctation, and dissection of the ascending aorta and aortic arch are often associated conditions that complicate patient management and increase morbidity and mortality. These associated aortopathies are commonly attributed to turbulent hemodyn...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.103.1.e7